Specification OF Specification FIPV GS-441524

• Appearance: Transparent liquid, white tablet, white powder

• GS Standard: 99.5%min

• Size: 5,5ml/vial, 10vials/box

• Content : 20mg/ml, 5mg/tablet, 99.5min

 

 

General FAQs About Treating FIP Using GS-441524

These questions and answers about using GS-441524 come from the FaceBook page FIP Warriors using GS.  While this is a closed group, they welcome anyone who faces FIP and wants to explore the use of the only available source of GS-441524 today. While these drugs are unregulated by any governmental agency, they are proving effective at treating FIP

DISCLAIMER

Please be advised that while we provide below information we do not sell,market, advertise or otherwise offer any GS products or provide any guarantee or warranty of any kind or make any representation or otherwise confirm the concentration and/or biological activity of any GS products. We are not affiliated with, or have any connection to, any GS manufacturer or supplier and thereby cannot make any guarantees or representations of any kind in respect of any GS products. We are the cat owners whose cats are affected by incurable medical condition for which effective treatment is not available in theUnited States either through commercial or clinical means and we are simply sharing information otherwise available on the internet. We do not commercialize or promote any GS products, however, we are not aware of any unreasonable risk related to GS products and we believe that GS-441524 doessatisfy GRASE criteria established for animal drugs by the FDA.

WE HEREBY DISCLAIM ANY AND ALL LIABILITY, RESPONSIBILITY,WARRANTY, REPRESENTATION, GUARANTY AND/OR OBLIGATION OF ANY KIND WITH RESPECT TO ANY GS PRODUCTS. FURTHERMORE, BY PARTICIPATING IN THIS GROUP IN ANY MANNER WHATSOEVER, YOU IRREVOCABLY CONFIRM THAT YOU ARE ACTING IN YOUR OWN PERSONAL CAPACITY AND AT YOUR OWN RISK, YOU ARE SEEKING INFORMATION ANDGS PRODUCTS STRICTLY FOR PERSONAL USE IN COMPLIANCE WITH ALLFDA RULES AND REGULATIONS AND YOU HEREBY WAIVE, RELEASE AND RENOUNCE ANY AND ALL CLAIMS AGAINST THIS GROUP AND ITS ADMINISTRATORS AND MODERATORS

Q: What is GS?

A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.

It is currently available as an injection or an oral medication although the oral version is still not widely available yet. Please ask an admin!

Q: How long is the treatment?

A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.

Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.

Q: What is the correct dose of GS to give my kitty?

A: Dosing is based on the weight of the cat. Below is a very good online tool for calculating the correct dose for your cat. https://reference.medscape.com/calculator/weight-dosing

If you love math, the formula to calculate is:
5mg*(GS) x weight(kg) / GS concentration per 1mL**=dose per 24hr

*Neurological and Ocular FIP cats require 8mg/kg MINIMUM.
Can go as high as 10mg/kg for extreme ocular or neurological cases.
*GS concentration per 1ml = total GS in bottle (mg) / total solution volume (mL)

Q: What exactly are “neuro” or “ocular” cases?

A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:

 

Q: How much does the 12 weeks of treatment cost?

A: Each 5 mL bottle of treatment costs from $80 - $358 depending on the brand.

Dose will depend on the weight of the cat - each bottle of GS is 5mL liquid at either15mg or 16.57 mg concentration depending on the brand purchased.
12 weeks of treatment can cost anywhere from $1,100 - $11,000 USD depending on the brand of GS used and the weight of the cat.‍

Q: Why are the prices so varied?

A: The different manufacturers charge different prices. Think of it like Rolls Royce and Toyota. Both great cars but very different price points. Mutian brand whichsells for $358 per bottle guarantees a cure if you use their products for 12 weeks.If your cat relapses or isn’t cured, they will provide free treatment until the cat iscured. They also offer oral medication. See next page for details on the oral meds.The second brand that charges $80 per bottle is a bit newer to the market but is also working well for the cats in our group currently using it. Both weretested for biological activity at a leading US university lab and appeared to be asadvertised. You may see additional brands of FIP treatment in other FB groups butwe have not tested those and do not endorse them.‍

Q: What are the details with the oral treatment?

A: Mutian Oral Pills:
Dosage is 1 pill equals 0.3 ml of Mutian II.
Neuro dosage: Please contact us for dosage. We would have to calculate and itdepends on all different cases.
Price is $20 per pill but buy 4 get 1 free. So in lots of 5 it comes to $16 per pill.Please place all orders for Mutian pills by sending PM to Nancy Schmidt-Moulenand you can reach her for any Mutian pill questions that you might have.

‍Q: How do I buy the FIP treatment

A: Please contact any admin in the group for help getting the treatment.

‍Q: How do I know the FIP treatment I am buying is the real thing and will work?

A: While we randomly tested the two brands of FIP treatment we discuss in this group and confirmed biological activity and acidity as claimed by the sellers, thegroup cannot and will not provide any guarantees. All cat owners using GS are doing that at their own risk. We can only share our experiences and successes we had.

Q: What size syringes and needles do I need?

A: Depending on what your cat’s dose is, you can used either a 1 mL or a 3 mL syringe. Use a 20 gauge needle to draw up the GS into the syringe and then it’s best to CHANGE the needle to a fresh one of the same size OR SLIGHTLY SMALLER (21 or 22 gauge) to inject. The GS liquid is somewhat thick and a larger needle allows it to be drawn up and injected faster. The LENGTH of needle can be anywhere from 1/2” to 1 1/2” in length. It’s a bit of a personal preference. Some usethe longer needles to try and avoid any GS leaking out, some are more comfortable injecting with a shorter needle. You DEFINITELY want Luer-lock needles so they can be secured to the syringes and not pop off.

A NOTE ON NEEDLE GAUGE SIZES: The number used to describe the circumference or “width” of the needle opening gets larger as the size of the opening gets smaller. For example, an 18 gauge needle has a larger opening than a 21 gauge needle.
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Q: Where do I get syringes and needles?

A: Hopefully your vet can start you out with a few syringes and needles. They can also be ordered from:
• https://smile.amazon.com/ch/81-3627434‍

• Valley Vet Supply https://www.valleyvet.com/‍

• MedLab Supply https://www.medical-and-lab-supplies.com/

• Care Touch https://www.caretouchusa.com/

Insulin syringes are NOT recommended unless you change to a larger needle.The insulin needles are too small for the thickness of the GS to pass through them.

Q: How do I give the GS injections?

A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet.

 

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Q: What are the side effects of GS?

A: The only known side effects of GS are pain during injections and the possibility of skin lesions forming at the injection sites.‍

Q: My kitty is on GS and now has diarrhea. What should I do?

A: We recommend giving B-12, bland food and a probiotic. Pumpkin puree is also okay to give. Fortiflora or Proviable are two probiotics. If the cat seems to be getting dehydrated, giving sub-cutaneous fluids is okay

Q: What supplements do I give during GS treatment?

A: Many of our members use a variety of supplements during GS treatment to support organ and immune health. Dr. Pedersen believes that if you are using GS, you don’t need anything else so “save your money”. It’s a personal choice and below are some of what our community is using along with GS:

 

Q: Can I just buy the GS in powder form and mix it up myself?

A: You need some degree of expertise and the right equipment to prepare the diluent, adjust the pH, accurately weigh small amounts of drug, suspend- ing it in diluent, and fully solubilizing it by readjusting pH and sonication. Some of the chemicals such as concentrated HCl are also dangerous in the hands of novices and technically the drug should be handled with gloved hands and with some care. People were having extremely difficult time doing these things and were continually asking advice, which is hard to give to ordinary people with no equipment.

Q: Where do I get syringes and needles?

A: Hopefully your vet can start you out with a few syringes and needles. They can also be ordered from:
• Amazon.com

• Valley Vet Supply https://www.valleyvet.com/‍

• MedLab Supply https://www.medical-and-lab-supplies.com/

• Care Touch https://www.caretouchusa.com/

Q: How do I dispose of all of the used needles or “sharps”?

A: This link is a great resource for finding a sharps disposal location near you: https://safeneedledisposal.org

You can also purchase something like this for about
$4 at your local pharmacy and they might even take it for disposal when it’s full of sharps!

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Q: Should I continue to use flea/tick treatment for my FIP kitty during treatment?

A: No. Do not use Revolution, Frontline or other chemical flea/tick treatments while on FIP treatment. The biggest part of treating for fleas is the environment. Vacuum daily (floors, closets, bedding, anything the cats come in contact with) and wash all bedding. You can flea comb your cat daily to remove fleas. You can make a mixture of water and apple cider vinegar (2:1) to apply on a cloth and wipe onto your cat daily so the fleas don’t want to be on her. Revolution is one of the moresafe options, but I would hesitate to combine it with GS for fear of affecting the GS being able to have full effect.

Q: Should I vaccinate my FIP kitty during treatment?

A: No.

Q: How long after completing FIP treatment should I wait to spay/neuter my cat?

A: 3 months.