CAPE; Caffeic Acid Phenethyl Ester Phenethyl caffeate CAS#104594-70-9 1kg/bag

CAPE; Caffeic Acid Phenethyl Ester Phenethyl caffeate CAS#104594-70-9 1kg/bag

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Product Details

CAPE; Caffeic Acid Phenethyl Ester, Phenethyl caffeate CAS#104594-70-9, 1kg/bag

Introduction

· Latin Name:CAPE; Caffeic Acid Phenethyl Ester

Phenethyl caffeate/104594-70-9

· Test Method:HPLC

Propolis is a resinous substance that bees collect from tree buds or other botanical sources. It is used as a sealant for unwanted open spaces in the hive. Propolis is used for small gaps (approximately 6.35 millimeters (0.3 in) or less), while larger spaces are usually filled with beeswax. Its color varies from green to reddish brown depending of its botanical source; the most common being dark brown.

 

For centuries, beekeepers assumed that bees sealed the beehive with propolis to protect the colony from the elements, Such as rain and cold winter drafts. However, 20th century research has revealed that bees not only survive, but also thrive, with increased ventilation during the winter months throughout most temperate regions of the world.

 

 

Function

 

Caffeicacidhasbeenshowntoinhibitcarcinogenesis,althoughotherexperimentsshowpossiblecarcinogenic

effects.Itisalsoknownasanantioxidantinvitroandalsoinvivo.

 

Caffeicacidalsoshowsimmunomodulatoryandantiinflammtoryactivity.Caffeicacidoutperformedtheotherantioxidants,reducingaflatoxinproductionbymorethan95percent.ThestudiesarethefirsttoshowthatoxidativestressthatwouldotherwisetriggerorenhanceAspergillusflavusaflatoxinproductioncanbestymiedbycaffeicacid.Thisopensthedoortousingnaturalantifungicidemethodsbysupplementingtreeswithantioxidants.AnotherstudyalsoshowedthatCAPEsuppressesacuteimmuneandinflammatoryresponsesandholdspromisefortherapeuticusestoreduceinflammation.

 

 

Application

 

Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have

 

1. Anti-mitogenic,

 

2. Anti-carcinogenic,

 

3. Anti-inflammatory,

 

4. Anti-cancer

 

5. Immunomodulatory properties.

 

A potent and specific inhibitor of the activation of nuclear transcription factor NF-KB. It is also exhibits inhibitory activity against HIV-1 integrase with IC50 of 7uM.

 

Specification

Item

Specification

Result

Appearance

Whitetolightyellowcrystallinepowder

Complies

Relatedsubstance(HPLC)

Totalimpurity≤0.5%

Singleimpurity≤0.1%

0.2%

0.06%

Odor

Characteristic

Complies

Assay

99%

99.8%

Sieveanalysis

100%pass80mesh

Complies

LossonDrying

ResidueonIgnition

≤1.0%

≤1.0%

0.12%

0.09%

HeavyMetal

<10ppm

Complies

As

<0.1ppm

0.05ppm

Pb

<0.1ppm

0.05ppm

Cd

<0.1ppm

0.05ppm

ResidualSolvents

<100ppm

Complies

ResidualPesticide

Negative

Complies

Microbiology

 

 

TotalPlateCount

<1000cfu/g

Complies

Yeast&Mold

<100cfu/g

Complies

E.Coli

Negative

Complies

Salmonella

Negative

Complies

Reference

1.Hydroxylated aromatic inhibitors of HIV-1 integrase: T.R. Burke Jr., et al.; J. Med. Chem. 38, 4171 (1995) Abstract
2.Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B: K.
3.Natarajan, et al.; PNAS 93, 9090 (1996) Abstract
4.Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells: C. Chiao, et al.; Cancer Res. 55, 3576 (1995) Abstract
5.Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation: P. Michaluart, et al.; Cancer Res. 59, 2347 (1999) Abstract
6.Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation: Z. Orban, et al.; Neuroimmunomodulation 7, 99 (2000) Abstract
7.Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors: N. Marquez, et al.; J. Pharmacol. Exp. Ther. 308, 993 (2004) Abstract
8.Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties: F.M. da Cunha, et al.; Free Radic. Res. 38, 1241 (2004)

 

 

 

 

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